Gareth Bale is suspended for Spurs after picking up a yellow card in the first leg while Clint Dempsey has not yet recovered from a calf injury.
Younes Kaboul and Sandro are long-term absentees but Aaron Lennon and Emmanuel Adebayor have both travelled with the squad despite missing last weekend's trip to Liverpool.
Inter Milan have not selected Alvaro Pereira, Dejan Stankovic, Ezequiel Schelotto and Marco Benassi for the squad while Argentine duo Diego Milito and Walter Samuel are missing through injury.
What they say
Spurs boss Andre Villas-Boas said: "There is no scoreline that could make us change six or seven players so we will play a strong team to make sure we go through in this competition.
"We take this game very seriously."
Inter Milan coach Andrea Stramaccioni said: "We want to do well and honour [the tournament], but we know our situation and our numbers are limited.
"Football is strange. 3-0 is difficult to overturn, but we'll be taking to the field to win."
Where it will be won and lost
Tottenham dominated the first leg and could have easily come away with an even stronger advantage than 3-0.
The mindset of Villas-Boas' side will be key. Inter are unlikely to be as poor in front of their home supporters as they were at White Hart Lane and the Italian side have nothing to lose.
If Spurs don't start with the right attitude they could be in for a nervy night.
Tottenham are unlikely to reproduce the demolition display of the first leg particularly without Bale and Inter will be out to prove a point. The Italians might do that but they won't overturn the deficit.
Inter Milan 2-1 Spurs