Major resurfacing work on the North Circular is set to start tomorrow.
The work on the A406 North Circular Southend Road, between the Waterworks Roundabout and Charlie Brown Roundabout, South Woodford, will be completed at set times until late October.
The majority of the work will be done at weekends between 10pm on Friday and 6am on Monday and when required there will also be weekday overnight work between 10pm and 6am.
The 123 bus will be diverted and information about this will be posted at the bus stops.
Transport for London said it will try to do the noisiest work before midnight.
In a statement on their website, TfL said: "This work will ensure the road can continue to serve the area for years to come and will provide a better road surface, helping to reduce noise and the need for ongoing maintenance in the future.
"The essential refurbishment works have been phased and coordinated to take place during the summer when traffic levels are significantly lower, helping to reduce the impact on road users.
"Drivers are advised to check before they travel and allow extra time for their journeys, as these works will have an impact on a wider area than the immediate vicinity of the works and, where possible, change their routes to avoid the disruption."