The ticket office at South Woodford station will close on March 16, it has been announced.
New ticket machines are set to be installed at the station under Transport for London (TfL) plans to save £4.2bn by 2020.
Up to 900 jobs are set to be lost.
TfL's Nick Brown said: "We are moving our staff into the ticket hall where they can assist you more effectively, the station will continue to be staffed between the first and last trains.
“The station will have smarter ticket machines, offering guidance in 17 languages, making paying for travel easier.”
The next wave of ticket office closures on the Central line will take place between April and June.
These include Leyton, Snaresbrook, Wanstead and Woodford stations.
Between July and September, Buckhurst Hill and Leytonstone offices will close.
Then from October to December, offices at Debden, Epping and Loughton stations will be shut.
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