The Guardian Series is hoping fans will enjoy interacting pre-match, during the game and after the final whistle has blown on our website.
Twitter users can contribute just by adding the #lofc hashtag and for those of you not on the social networking site, you can still read the comments here and add your own views in the comment section below.
If you have any questions for our reporter about the match or other Orient related matters then you can contact him via Twitter by tweeting @GuardianOrient.
• Leyton Orient named an unchanged side for the match after Saturday's 2-1 win over Notts County.
•The O's earned a 1-0 win at Swindon Town back in September which was their first league points of the season.
Leyton Orient line-up
Jones; Sawyer, Chorley, Baudry, Cuthbert; Cook (Cox, 66), Rowlands (Smith, 78), James, Odubajo; Mooney, MacDonald
Subs not used: McSweeney, Griffith, Symes, Obafemi, Omozusi
Swindon Town line-up
Foderingham; Devera (Flint, 35), Thompson, Ward, Ferry; Ritchie, McCormack, Miller, Collins (Martin, 62); Williams, De Vita (Roberts, 78)
Subs not used: McEveley, Navarro, Rooney, Bedwell