Russell Slade has dropped top-scorer David Mooney for today's trip to Sheffield United, preferring Kevin Lisbie as the lone forward in a 4-5-1 system.
Lloyd James returns to the side in Mooney's place, with Elliot Omozusi coming into the side in place of Gary Sawyer.
Mooney is part of an attacking bench which includes fellow forwards Shaun Batt, Chris Dagnall and Robbie Simpson.
Sheffield United: Howard; Brayford, Maguire, Collins, Freeman; Flynn, McGinn, Doyle (c), Coady, Murphy; Porter.
Subs: Long (GK), Harris, Hill, Paynter, Scougall, Davies & Dimaio.
Leyton Orient: Jones; Cuthbert, Baudry, Clarke (c), Omozusi; Odubajo, Lundstram, James (c), Ness, Cox; Lisbie.
Subs: Larkins (GK), Sawyer, Mooney, Batt, Gorman, Dagnall & Simpson.