Champions Southminster St Leonards ended the season with an unbeaten home record following a 1-1 draw with Newbury Forest on Saturday.
Tom Hine was the Southminster goalscorer, with Matt Wallis grabbing the Forest strike.
White Ensign were relegated to Division One after losing 2-1 to Hannakins Farm.
Welcome Mtsali got White Ensign's consolation goal as relegation was confirmed.
Manford Way were thankful for Ensign's demise as they lost 3-0 to Frenford Senior.
Ensign's defeat means they can no longer catch Manford, who sit just a place above them with one to play.
Damon O'Neil, Brad Foley and Carl Conway scored the Frenford goals.
Harold Wood Athletic also secured their top-flight status with a 5-2 win over Buckhurst Hill.
Kevin Ayres bagged a brace from the penalty spot, with Tom Potter, Ade Onielyan and Jordan Marsh all scoring for Harold Wood.
Kelvedon Hatch claimed a comprehensive 4-1 victory over May and Baker EC to take another step towards second place.
Stephen Willis notched twice and there were further strikes from Lee Newton and Michael Daniels. Garry Mackin scored for May and Baker.
With four still to play, Kelvedon Hatch can overcome Frenford in second if they win each of their remaining games.
Harold Hill were beaten 3-2 by Rayleigh Town.
Peter Beaumont, John Wheatstone and Ross Webster scored Rayleigh's goals, with Ricky Reid and Liam Briggs the Hill scorers.
The win sees Rayleigh edge closer to clinching a top-three finish.
Canning Town and Galleywood shared the spoils in a 1-1 draw on Saturday.
Arron James scored for seventh-place Canning before George Nash replied for fifth-place Galleywood.
Epping ended the season in style, thumping Forest Glade 5-3 on Saturday.
Jake Clarke scored twice, with Sean Green, Chris Wright and Tasfie Taylor also netting for Epping.
Enyam Grant also grabbed two, with Grant Cumming the other Glade goalscorer.