Russell Slade starts new-boys Jobi McAnuff and Jay Simpson amongst the substitutes, with Darius Henderson - signed yesterday - not involved in the matchday squad for this afternoon's visit from Ipswich.
The O's starting XI sees four changes from the side which drew 2-2 with Queens Park Rangers on Tuesday, with Adam Legzdins, Shane Lowry, Shaun Batt and Chris Dagnall all coming into the side.
Gary Woods, Scott Cuthbert, Dean Cox and Kevin Lisbie all drop out.
Leyton Orient: Legzdins; Omozusi, Clarke (c), Baudry, Lowry; Pritchard, James, Vincelot, Batt; Dagnall, Mooney.
Subs: Sawyer, Cox, Lisbie, McAnuff, Lee, Okosun, Bartley, Nikolaou, Simpson & Woods (GK).
Ipswich Town: Gerken; Mings, Berra, Chambers (c), Parr; Hewitt, Tabb, Skuse, Hyam; Murphy, Bajner.
Subs: Bialkowski (GK), Clarke, McGoldrick, Bru, Wordsworth, Henshall, Stewart, Nouble, Marriott & Crowe (GK).