Fabian Balbuena and Javier Hernandez have joined West Ham's injury list ahead of the trip to Southampton.
Defender Balbuena suffered a knee injury against Watford on Saturday and striker Hernandez came off with back and hamstring problems.
They join Lucas Perez, Marko Arnautovic, Jack Wilshere, Andriy Yarmolenko, Manuel Lanzini, Ryan Fredericks, Carlos Sanchez and Winston Reid on the sidelines.
Provisional squad: Fabianski, Zabaleta, Diop, Ogbonna, Masuaku, Rice, Noble, Snodgrass, Anderson, Antonio, Carroll, Adrian, Cresswell, Obiang, Diangana, Coventry, Silva, Powell.
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